A motorbike rider is dead and three other people have been rushed to hospital, following a four vehicle crash on the Waterfall Way west of Bellingen.

The road was closed for a number of hours as police worked to determine the circumstances surrounding the crash, with road blocks lifted at around 8 o’clock.

It’s understood an eastbound motorcyclist collided head-on with a car at around 4 o’clock in the afternoon, around 13 kilometres west of Bellingen.

The rider, who is believed to be from Coffs Harbour died at the scene.

A 31-year-old woman, who was behind the wheel of the car was taken to hospital for mandatory testing.

Three others were taken to the Coffs Harbour Health Campus suffering minor injuries.