The Titans will field one of their most inexperienced teams ever when they take on Penrith in Darwin.
Titans under 20s duo Jahrome Hughes and Hymel Hunt have joined the team in the top end, making their NRL debuts.
They replace William Zillman, who’s out with a groin injury, and Jamal Idris, who has a broken leg.
Saturday’s clash counts as a Titans’ home game.
