A police investigation is underway after a serious two-vehicle crash on the Central Coast.

Emergency services were called to Wilfred Barrett Drive at Magenta, just north of The Entrance, after 6pm on Sunday.

Police were told a black Hyundai Coupe and a white Toyota Prado crashed head-on.

The Hyundai driver, a 23-year-old woman, and her passenger, a 28-year-old woman, were treated at the scene for significant pelvic, leg, rib and internal injuries.

The two women were airlifted to John Hunter Hospital, both in a serious condition.

The Toyota driver, a 16-year-old girl on a learner licence, and her passenger, a 53-year-old man, were not seriously injured.

The teenager was taken to Wyong Hospital as a precaution.

The man gave a roadside breath test, which returned a negative result.

Police set up a crime scene, which was examined by the Crash Investigation Unit.

Anyone with dashcam footage is being urged to contact police.