Police are seeking public assistance to locate a man missing from Grafton.

67-year-old man Garry James Ellem was last seen leaving his Greaves Sreet home around 8pm yesterday.

There are concerns for his welfare as Mr Ellem suffers from several medical conditions that require medication.

He is described as being of Caucasian appearance, of medium build, about 165cm tall, with brown hair and blue eyes.

Police have been told he may be travelling in a gold Holden Commodore sedan with NSW registration GKE-111.

Anyone with information is urged to contact Crime Stoppers.